According to the Slavic-Aryan spiritual heritage, even on the night of Svoraga, human life can reach 432 years (3 more circles of life for 144 years). In the coming from 7521 Summer (2012) Morning Washer Duration of our life increases at least for one life circle. Given the average life expectancy of the population of Russia (about 70 years), all sensible people should think about the fact that the health of society is in a deplorable state. After all, it is possible to live in our time and you need not 432, but 576 years old. And certainly not 70!

It is worth noting that, according to the Vedic Scriptures of our ancestors, those who, following their Rock (destination), live in accordance with Dharma (prescribed duties), reach a high level of spiritual development and do not violate the Lad of the Universe, live several thousand years. Of course, such a life expectancy should be disposed of good health and well-being.

An important foundation of our health and well-being is healthy teeth. The teeth not only help us chop food, but also directly related to the processes of her assimilation by the body, not limited to the digestive system. Teeth (with some sharing) can be compared with a needle of the pickup in the player, with which it recognizes and reproduces the record from the plate. The teeth permeate the aura of food during her chewing and read from its biofield "Instructions" on the use of this food for the body.

If the food is healthy, live, that is, raw (vegetables, fruits, nuts, root ...), in her biofield there is a "code" for our bioflash - what to learn, and what to reject (growth accelerators, keriformicates - immediately discharge). If food is not entirely healthy (boiled and fried vegetarian products), the biopol of our teeth is distorted by the biopolem not completely healthy food, and the body cannot read it "instructions", because Its natural biofield is killed during heat treatment. If food is the flesh of innocently killed living beings (meat, fish, fertilized eggs), the biopol of the teeth is defiled by the energy of such food. At the same time, in the biopol of the teeth and in the whole aura of such a Troaded, the karma kill is injected, the energy of the curse of the patrons of these living beings, as well as the energy of fear, mortal torment and hatred for people who are permeated by the flesh of the brothers of our smaller killed on the whims of the elders, Staying in the marker of ignorance. Naturally, the teeth from this very quickly destroy.

Modern dentistry offers to remove patients with teeth and replace them with artificial prostheses. However, recently there is increasing information that a person who has refused to death and then, and not completely healthy food (albeit a vegetarian, but heat-treated), it is capable of managing rehabilitation processes in its body and grow in return Teeth - new.

There are certain methods for growing new teeth.

In order to grow new teeth, you need to know well anatomy and their structure.

Before the start of the restoration of the teeth, it is desirable to find out the true causes of their destruction, falling out or illness to make the right conclusions for the future.

Doctor of Medical Sciences, Professor of the Moscow Central Region of Dentistry Gennady Banchenko is convinced that teeth diseases arise under the reasons described above, as well as due to internal problems in the body. He correctly believes that every fearing tooth is directly related to the unhealthy of some of the internal organs of our explicit body.

Ekaterina Slobodskova introduces some bio-energy concepts into the relationship of teeth and internal organs, in particular, the system of energy bodies of man. According to Catherine, the left side reflects the interaction with God, with relatives, right - with other people surrounding, with society.

Teeth communication circuit with internal organs and spine vertebrae:

The right side of the obvious bodies of residents, people and people are connected with their gods, and the left - with the goddesses of patrons and, accordingly, with their births on the male and female line of the genus. In accordance with this knowledge, they understand the causes of diseases not only to the teeth, but also other organs of the explicit body, as well as, the rest of the bodies and the shells of their co-knowledge with the Almighty Pratcher.

Check out the video about the regeneration of new, young teeth at any age:

Description of the practice of growing new teeth:

1. The first thing to do is to remember as much of all sensations as possible, which accompanied the growth of new teeth in childhood. It is easy to do - nature has already tried and gave us the memory of it through pain (all painful feelings are the strongest and remembered for a long time). Remember this permanent itching in guys, how old teeth are swinging, which are "pushing" from the bottom of growing young teeth. Remember yourself facing a mirror with a thread attached to the tooth overcoming your fear and pulling it along with the tooth. Remember this because it is the first "button" that "will turn on" and launch the growth process of new teeth.

2. Now remember that the first teeth begin to grow from the first two lower cutters and they begin to change new ones from them. This suggests that here is another of the "buttons", for which you need to click to include the process of growing new teeth.

3. The third "button" is in our knowledge with the genus-progenitor. It needs to be "included" into a permanent mode so that it acts all 24 hours a day in cooperation with God.

1. Find 10-30 minutes for classes every day. Think of one third of this time about space under each tooth and at the same time feel the space under each tooth inside the guise. In this space, imagine small white teeth, like seeds that just germinate. Think about these new young teeth exactly how about the seeds that are planted and starting to germinate. Remember (from the first point of the practice of growing new teeth) itching, which accompanied the growth of new teeth in childhood, as they "scratched", as they were painfully germination through the guys, etc.

2. Hold the concentration on this during the first third of the practice.

3. Next, without stopping the concentration described above (teeth-seeds, itching in dears), concentrate on a point that is under two lower front incisors (this is the gum area at a depth, about 0.5-0.8 cm.). As concentration gained, the pressure should be felt in this area. It is good, it means everything is going on correctly.

4. Hold the concentration on this during the second third of the practice.

5. Not stopping both concentrations described above (at the guys and at the point under the front cutters), concentrate, also on the area between the eyebrows and the cisheloid iron of the brain (on the third eye), mentally uttering words: "My teeth are completely updated! Patients - fall out, and young and healthy - grow up "! At the same time, create a tolerant of updating your teeth - brightly presenting, and then, seeing this internal eyes.

6. Make this practice is needed for at least a month. Of course, someone may need less time, and someone else. Therefore, the main rule of U-Spec in this matter is the ability to feel their body.

Note:

The only reason for the negative result in this practice may be the fear of losing their teeth and clinging for "domestic worn" - the worldview of ignorant inhabitants who do not believe or nor the gods that do not trust the universe. For example, the assumption of thoughts: "What if all the rotten teeth fall out, and the new will not grow up," "Better Tit is in hand than a crane in the sky", etc. In this case, you can never start. First, get rid of inferiority complexes.

1. It is necessary in its pre-treatment, or in co-grazing (meditation), transfer to age for 13-15 years, when all the milk teeth have already gone, and indigenous is still healthy. It is necessary to imagine the feeling of healthy and strong teeth at this time in this time. To do this, you can use your photos. Remember as much bright moments as possible from this period of life ... For example, as you gnawed strong nuts, "Khrumkali" vegetables and root.

2. It is necessary to enter the co-knowledge, imagine the thought of the embryos of healthy teeth into the vestments you need. It is necessary to give a clear order to the teeth grow alternately (according to the above scheme). Subsequently, it is necessary to constant mental admonness of healthy, beautiful, shiny, white teeth.

3. Daily, and better - hourly make the most attention to the right place to be the right place, constantly reinforcing (physically and psychologically) blood flow into this place, massage the guys with a toothbrush, jaw training. It is hourly (every hour to 5 minutes) lovingly praise the cells of their adhesion for growing new teeth. Train your jaws: Squeeze your teeth for a short time, then let go, move from side to the side. Make massage in the tongue, fingers.

If the teeth in the mouth are completely small, then to start their cultivation should be as mentioned above, from the front teeth, to the edges. If you restore one or two tooth, then concentrate only on them.

To help you also have these configuration-meditations for teeth growth.

How to grow new teeth (meditation №1):

Practice of regeneration of new, young teeth (meditation number 2):

Regeneration of teeth (meditation №3):

After the prosperous cultivation of new teeth, try to ensure the body healthy and full nutrition, as well as caring care of your teeth. Just do not use toothpastes. In the extreme case, the tart powder from the chalk is suitable. But it is better to use the natural cleaners of the teeth, which can be found from the suitable Vedic Scriptures belonging to yoga. For example: Aura Veda (Aurweda), Ha-Tha Yoga, Knaging (Rhnana) Yoga, Karma Yoga, etc.

As for the treatment of caries:

At the beginning, in theory, the Caries himself should be walked, to play a dark fall, and the cavity filled with dark energies, a black visual tooth, whiten. First step.

And when dark energies are burst out of such cavities, the tooth will be sweeping out of dark, dirty energies, this cariesta rot-rust will be held, it is possible to engage in revival and recovery. This is the second stage. You can fill out the ex-sick tooth tooth energies of health, make balls, drive light essential energies containing wellness information, such program balls, that the teeth are healthy, white, strong, resistant to warm and cold, to overheating and overcooling.

It should be remembered that each of us came to this world with his rock (destination) and loss of health, with subsequent hasty leaving of life, puts the execution of your rock at risk.

Currently, all sane people must realize the importance of reviving the culture and knowledge of the ancestors, restoring the health of the Slavic-Aryan kinds and community lifestyle, a conscious attitude towards life and informed behavior in society.

The main disadvantage of our teeth is that they grow only from two groups of adventures formed during the period of intrauterine development. Milk crowns appear from the first group, from the second - permanent.

With a loss of a constant tooth, it can be replaced only by artificial, which cannot fully perform natural functions, and in this case the procedure is not shown to everyone. It pushed scientists to the idea of \u200b\u200bgrowing human teeth.

To date, after holding a large number of research and experiments, to grow a tooth still succeeded.

From the history

The first developments on this project were started. in England in 2002. For his experiment, a group of scientists used crowns pigs six-month age I. rat.

The research group was headed by Pamela Yelik. The piglets were sept Uncooked dental tissue cells that placed In enzymes.

Innovation in Stomatology

After their cell formation transfer On the polymer plate, which in the process of cell development gradually decomposed. Fully formed primators dried rats.

Exactly after 3 months, new crowns have appeared in rats, having a defective dentin, the complete lack of enamel and inconsecable root.

Based on previous studies, the experiment continued scientists from the University of Sciences of the city Tokyo in 2007. Takasi Tskuji together with colleagues were able to grow new teeth and successfully enlist them with young mice.

Restricted organs fully performed their functions. They had formed dental fabrics and they had no root part.

The best result was achieved the same group, but already in 2009. For its study, Tokyo scientists used a different technology other than that was applied earlier. For the formation of the root, they took mouse cells, responsible for the development and growth of teethand stimulated their growth in the collagen environment.

Then satisfied Configuration at the place of remote crowns. In their place, normal teeth with a full-fledged coronal and root part rose. During growth in the pulp was formed nervously vascular beamresponsible for further nutrition of dental tissue.

Genes.

For the identification of a gene responsible for the growth of teeth, scientists of Zurich University took. They revealed that the processes are responsible for these processes. gene Jagged2. and chromosome plot titled Notch. It was revealed that in the absence of activity of this NOTCH gene begins to work with pronounced errors.

Based on the obtained data, scientists continued to study and allocated the gene responsible for formation of the correct position of the crown - OSR2. With its deactivation, the deformation of the dentition with the growing crowns beyond, as well as the formation of wolf grazing.

Growing new teeth in humans artificially

Behind initiation of the formation of ads Gen is responsible MSX1. The experiment showed that in the presence of this gene and when the others are disconnected, the individual bodies have developed. But when they are activated and disabled MSX1, no development of adventures did not occur.

Based on the data obtained, scientists came to the conclusion that it is impossible to grow the cultivation of the teeth without the MSX1 gene.

Stem cells

Professor Mitsiadis after a detailed study of the dependence of the activity of genes and the development of adventures revealed that genes.responsible for their formation take an active part in the production of stem cells Dental fabrics.

Based on this, some scientists began to believe that with anomalies of a number of teeth caused by genetic factors, stem cells can be used as therapy for recovery.

These cells are the only ones with the ability to restore damaged organism cells, replacing them by their division.

For the formation of crown The stem cell is satisfied with an empty alveolar well and leave it alone. Over time there is formed new germ and then tooth.

In this case, the growth process is accompanied by the same sensations as in childhood. The shape of the crown and the root do not differ from the real teeth.

The only nuance of this method is that with age Number of stem cells hopelessly decrease. If at the age of 25 years one can detect one such cell per 100 thousand, then 50 years 1 cell falls on 500 thousand.

Moreover, the process of fence material To isolate cells very painful. Therefore, at the moment, scientists are more involved in the development of methods that would allow the material to carry out more efficiently and less painfully.

Animal experiments

Photo: Growing a real living tooth

The shocking complex of stem cells produced mice. In order to track the process in detail in detail, the cells of the green fluorescent protein mice were added to the cells.

This experiment ended with the appearance of a new tooth. Studies have shown the following:

• grown crown and root in their form they do not differ from a real tooth;
• anatomical structure included exactly the same elements.: Pulpu, vascular nerve beam, dentin, enamel;
• dental fabrics had high strengthallowing you to fully perform all functions;
• the size of the crown part was slightly less than standard indicators.

In this video, it is described about the techniques, thanks to which scientists managed to achieve the first results:

Methods

In theory for growing human teeth, 2 methods are presented: internal and external.

Interior

This method provides for growing directly in the oral cavity. The internal method was developed by the Ukrainian scientist and is to introduce stem cells into empty alveolar wells. To do this, he proposes to use cells isolated from fallen dairy crowns.

They are necessary enter the injection method for the mucosa. About 3 or 4 months there is active breeding of cells and the formation of the fiction. At the end of this period a new tooth appears.

At the moment, this method is the easiest, but long-term. In addition, he never received a detailed study due to the lack of funds for funding.

Outer

The outer method implies the formation of a tooth outside the oral cavity And then its further introduction into the hole of the alveolar bone for adheated. For this, it is proposed to use two methods of cultivation:

1. In organic culture. For this, the cells of primitive type are used: mesenchymal and epithelial. The combination of these cells is placed in a collagen frame for forming a fragile.

   Then we are then transferred to an organic culture and after 2 weeks get a tooth with enamel, dentin, vessels and pulp. These timelines are characteristic of the cultivation of the crown of the mouse, the size of which was only 1.3 mm.

2. In a special test tube. In this case, exactly the same cells and the principle of formation of the ensuing is used, but in the future it is not placed in the organic, but in the capsule.

   In order to ensure the growth of the crown, the capsule is introduced into the liver of the mouse. The timing of the formation of the tooth in this case is no different from the first method.

Soon, humanity will be able to grow by the cultivation of new teeth on their own

Side effects

Despite the success of all recent studies, these development still do not receive active development. This is primarily due to the side effects that can accompany this procedure.

When the tooth is subset or its cultivation it is impossible to control the growth rate of each item. With the normal process, the neuro-vascular beam should develop at the same pace as dentin.

Otherwise you can get initially pathological crownwhich can affect both the health of the oral cavity and on any system of the body.

There is also a problem associated with an immune response of the body on the introduced cells. Perceiving them as foreign bodies, immunity will reverse them every way.

To reduce the risk of such a situation to a minimum, the patient will have to take serious dosages of immunosuppressants, which can completely deprive him of immunity for life.

The main minus of the developments carried out is the lack of a combined approach in which all the nuances of this procedure and its consequences would be taken into account.

Criticism

Most of the scientists, even when studying already confirmed positive data, adhere to the opinions that it is useless, nothing significant development.

In their opinion, the unit cultivation of the tooth in the mouse still does not serve as proof that stem cells will always behave forecast.

In addition, these manipulations are conjugate with such the number of problems and questionswhich can not solve any scientist.

Also, many confuse the effectiveness of the fitness of artificially obtained fiction. Not so long ago, doctors were attempted implantation patient's own teeth from one piece of jaw arc to another.

This technique showed so much low percentage of survivalthat did not find widespread use in dentistry. Judging by the unsuccessful result of this method, a grown tooth, which differs little from its own, may also simply do not fit.

Many embarrassment and the moment that when the sublayer is a germ, it is difficult to predict the type of tooth, which will grow. For example, a mlaro or cutter will be switched on the site of the fang.

When will the service appear?

Inspired by a positive result, Tokyo scientists took over to further study in this area. To date, they successfully work on the differentiation of the generated adventures, which would allow the exact positioning of the alveolar ridge site with the crown number.

New Dentistry of the Future: Growing Teeth

The scale and rates of research allowed scientists to assume that closer to 2030 The method of cultivation of a man's teeth will be widespread and gradually displaces prosthetics and implantation.

Price

According to scientists, this technique will have the same cost as standard prosthetics with the use of implantation, since its cost is not so high.

But if we take into account marketing market, then even with a wide distribution still not less than 10 years after its appearance in clinics This service will be the most expensive of all dental works.

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2 comments

• Katya

  October 8, 2016 at 13:45

  Two feelings after reading. It is not entirely clear what to grow to the tooth, which is also not known what will grow. Prosthetics, in my opinion, is now at a fairly high level. The materials used in the prosthesis are sometimes driving their own teeth. Duck should be so bother and risking health, it is not clear.

• Lina

  October 19, 2016 at 4:16

  Specialists in the field of dentistry apparently need to work well on the process of growing teeth. While it is still not completely harmless to humans and carries more harm than good. Although - the idea is not bad. In general, now there are enough methods that allow you to update your teeth. For example build, or prosthetics. The main thing is to find a good specialist.

• Dasha

  November 7, 2016 at 0:34

  Everything is developing and science does not stand still, it's good I believe, let the scientists develop and investigate this technique! Prosthetics of course option, but it is still, I think many will choose their choice on a more natural and natural tooth. When all risks are minimized, and the question is sufficiently studied, then the procedure is likely to become simple and familiar to all of us, as for example, the professional cleaning of teeth from the dentist or whitening (this is no longer surprised).

• Sasha

  January 17, 2017 at 9:50

  I agree with Dasha. It is not clear why there is no sufficient financing for scientific developments that help human health! What do people think about!? In my opinion, it is in scientific developments a happy healthy future. And the faster the ubiquitous implementation will begin, the better. Previously, potatoes were considered an inedible plant and used only its decoration flowers. Grow teeth, in my opinion, just ingenious. Why can not try shark cells?!)

• Svetlana

  April 4, 2017 at 3:59

  Prosthetics is now developed at a high level, this is a fact, but no super modern prostheses will replace natural teeth! It's good that science does not stand still. 20 years ago, they knew nothing about the same implants, and now used everywhere. The idea of \u200b\u200bgrowing teeth is just a grand! I hope for my old age, this technology will have time to implement and manage to do without removable jaws in a cup.

• Alexander

  September 23, 2017 at 6:08

  Well, what is done now and when such technologies will be available to the usual one?
  With regard to why such technologies are needed - the implant approaches the natural tooth on the aesthetic and functional properties, surpassing bridges and plug-in jaws. This is already progress and reasons to develop and implement new technologies. But the natural tooth allows not only to chew, but also to receive information, fully sensing food. Or all sorts of dirols with orbits :)))
  As for the cultivation of teeth and implantation - everyone eats and will be their niches. Who has chronic disorder in the body - artificial structures have their advantages: they are "over the situation." And who, who has a teeth are lost due to injuries or lack of culture of the care - the topics of the grown teeth and will be useful.

Toothpache is one of the most painful and most common. Incidentally, scientists and doctors offer not just to treat their teeth, but to grow differently damaged. With a report on this problem, the head of the Department of Pathophysiology, Professor of the Moscow State Medical and Dental University, professor of the Moscow State Medical and Dental University, spoke at the European Congress of Dental. Today, he answers the questions of the RG Observer.

Igor Yuryevich, about growing teeth say more and more. Messages from the USA, Japan, England, Finland, France, China ... and in your center stubbornly seek such a way of solving a deothip problem. All existing ways to get rid of teeth diseases are not the most effective?

Igor Malyshev: I would not want to be as categorical. The existing methods are very effective. But all of them have one common drawback: each method has its own limited period of suitability. Whether it is the most modern seal or the most modern implant. I really want that instead of the outstanding teeth were those who do not deliver any trouble and are perceived as their own. And studies show what it is quite possible.

Possible when?

Igor Malyshev: I can not call the exact date. Yes, and no one will call. While we do the following. There are two dental recovery directions recognized in the world. The first is the cultivation of the tooth from its primarily.

Where do you take the germ?

Igor Malyshev: And here again two ways. You can take it at the embryo. Such a procedure is possible only under a microscope. They took this gender from the embryo. Then they put it under the kidney capsule. Why kidneys? Yes, because there is very good blood supply. Perfect body temperature. And literally in two weeks a little teeth grows. This tooth can be sung in the jaw well instead of remote. And the process went: a normal tooth will grow.

How easy! How much did you go to such a result?

Igor Malyshev: The first were the Japanese here, and they went to him for ten years. It was easier for us, and we got the result for a year and a half.

But it has not been able to use the Japanese to take advantage of the medical practice of these results. Why?

Igor Malyshev: It is extremely difficult to get the trigger of the embryo tooth.

Do not throw away falling dairy teeth. They are a storehouse of stem cells

And the replacement of the embryo is not? The same stem cells from which they grow what you want, where you want ...

Igor Malyshev: Your question really torments the scientists of the whole world are already dozens of years. And indeed, methods have been developed with which from stem cells can be constructed the mains of the tooth.

Why not constructed?

Igor Malyshev: Designed. This is done. Bio-engineering teeth are obtained. But this is still an experiment. There is another second direction to create new teeth.

Is it necessary? First you do not reject?

Igor Malyshev: Do not reject. But the end result is important. That is, the transition from the experiment to the clinic. And the second approach is more clinically acceptable. It is to recreate the tooth with a biopinger right in the bowl of the tooth.

But in this case, do not do without a robot? Mistaken?

Igor Malyshev: Do not mistake. This is one of the advantages of this direction. That is, "print" a new tooth at any distance from the applicant of this tooth. University of Stankin and Laboratory 3D Solutions Bioprinting (3D Bioprinting Solutions) helps us implement this direction. Works in these two directions are headed by Corresponding Member of the Russian Academy of Sciences Oleg Yanushevich. You need to print alive dental cells, which will help to recreate the tissues of the tooth, and the whole tooth itself.

But where to get these live cells?

Igor Malyshev: They can be taken from the remote tooth. Its pulp contains them in due quantity.

And we throw away removed teeth ...

Igor Malyshev: Soon to throw out. Moreover, banks of storage of stem cells of the tooth of a particular person will appear. And more importantly, do not throw away falling milk teeth. They are a storehouse of stem cells. They must be kept carefully. Because of them, if necessary, you can grow not only your teeth. So it is possible to solve the problem of the deficit of organs and tissues for transplantation, and get rid of rejection of transplanted.

The rainbow future is waiting for us. But again: when?

Igor Malyshev: According to the most optimistic forecasts, it will take at least ten years. Maybe more. Although science is now developing unpredictable pace.

Growing new teeth - at least three rows, if desired, not far from the corner. Scientists have discovered genes that are responsible for the formation of dental enamel and the growth of whole teeth. And were able to at the discretion or deprive animal teeth or teeth Where it fell.

Researchers from the University of Zurich (University of Zurich) under the guidance of Professor Timios Mitsiadis (Thimios Mitsiadis) found that the incidents of the face and the dental system are formed during the period of intrauterine development from the epithelium and mesenchyma of the embryo. The violation of this process leads to the development of maxillofacial pathologies - defects in the development of teeth, hareting lips and wolf pastes.

Scientists have decided to conduct research on special transgenic mice to find out the scheme of temporary and spatial engagement of genes in the development of the dental system and face. And at the same time, and accurately determine which genes are responsible for caries and destruction of dental fabric.

Uzless mouse

For experiment, experimental animals were artificially violated the TBX gene transcription factor 1. The absence of this gene plays a fundamental role in the development of the syndrome Di George, in which a person develops a number of radiation of heart, thymus, parachite gland, face and teeth. As well as dental enamel, which the authors of the work are called the "most solid organic cloth".

Dental enamel, according to researchers, is formed by mineralization of certain proteins, which are allocated to the epithelial cells of the teeth - amlevable. These cells produce enamel until the tooth begins to cut out of the gums.

It turned out that the mice with the disconnected TBX 1 found a disadvantage and enamel, and in amlevable. True, laboratory animals lived not very long and scientists had to end the experiment on long-lived fabric cultures, which allowed to trace rising teeth to full maturity.

The connection between the production of enamel and genes also discovered Mitsiadis colleagues from Oregon University. True, according to their data, the lack of enamel affects the transcription factor of another gene - Ctip 2 affects the transcription factor.

Stem cell teeth

Scientists from Zurich also found out that TBX 1 is involved in the production of stem cells of the dental epithelium, which in turn form amoveloblasts. Therefore, Mitsiadis believes that in some cases, stem cells can be used for rehabilitation therapy in genetic anomalies of teeth. "These cells may come in handy for new transplant technologies," Professor explains, is an understanding of gene mechanisms that manage the growth and restoration of teeth will allow us to produce new products and tissues to replace injured and sick teeth. Although it is not worth doing only on stem cells. "

Mice with wolf mouth and shark teeth

Researchers from the medical center of the Rochester University (University of Rochester Medical Center), which is managed by Dr. Rulang Dzhang (Rulang Jiang), decided not to stop at studying the features of the origin of dental enamel. They decided to find out how the teeth themselves grow. And for this, they also turned to the face formation period during the development of the fetus.

For science again I had to "suffer with teeth" laboratory mice. Scientists have brought modified animals that "turned off" the OSR 2 gene - apparently "colleague" TBX 1. In its "area of \u200b\u200bresponsibility", the prevention of the deformation of the teeth and the appearance of wolf graze - a congenital defect, in which two half of the nose are not connected, Forming a gap.

"Embossing" OSR 2 led to the fact that the mice appeared on the light with the wolf mouth. In addition, they have grown their teeth for the limit of the normal growth line. This fact was so interested in Dzhanga that he decided to leave the wolf fall at the time alone and focused on learning paths growth of teeth.

The first sign of the formation of teeth in mammalian embryos is the thickening of the epithelium along the jaw line. This suggests that a group of cells have been formed, which is called a dental plate. Since all the teeth are subsequently formed from this record, scientists suggested that some special quality of epithelial cells makes them suitable for this process. Previous studies have shown that the teeth could appear from the epithelium, which is usually not involved in the dental plate. But how signals manifested for the growth of teeth outside the boundaries of the dentition, scientists did not know.

Research in other laboratories also showed that the bone morphogenetic BMP protein is needed to initiate the growth of teeth 4. It has its own "signal amplifier" - MSX protein 1. Therefore, Dzhang with colleagues suggested that there is some unknown factor that has limited in mice with a flaw OSR 2 Growth of teeth in one row, blocking BMP 4.

Further study showed that the concentration of the active GENA OSR 2 increases in the maintenance of the jaws towards the head to the tongue. And the concentration of BMP 4 increases in the opposite direction. Moreover, if OSR 2 does not work, the activity of BMP 4 applies beyond the limits of the dentition, and not limited to the dental plate. And then the teeth can grow far beyond the "traditional" for mammals of the tooth row.

Where to grow teeth

On this, Dzhang again did not stop. He decided to find out why mammals between teeth have a distance. And why sometimes it is not there and adjacent teeth looks woven among themselves. Therefore, researchers again took up mice, which also removed the OSR 2 gene, and the MSX 1 gene.

Experimental mice, which lacked only MSX 1, could not grow a single tooth. And those who have "turned off" both squirrels, and only the first native teeth were raised. The experiment allowed scientists to say that even if there is no putting teeth in place OSR 2, then the BMP 4 squirrel is quite enough so that something in the mouth is still growing. But without MSX 1, the BMP 4 signal was not intensified so that the construction of the next tooth began in a row.

Professor Dzhang suggested that BMP 4 cooperates with other factors for the formation of teeth and helps create a "demarcation zone" around each tooth, where nothing is growing. When the tooth is almost ripe, MSX 1 reduces the level of the prohibition on growth and the development of the next tooth, managed by BMP 4 begins.

As growing not only the teethBut the jaw, each tooth should receive a signal that the jaw bone is already enough for him. Here, according to Dzhanga, and the mechanism of formation of wolf pastes.

In the plans of the Rochester team - accurately track the genetic chain, which manages the copying of the teeth and the development of the sky. Well, in order not to lag behind the colleagues from Zurich, understand how the stem cells can be applied for the treatment of wolf graze. And growing teeth from scratch.

Materials about the difficult formation of the teeth in their place can be found on the website of the medical center of the Rochester University in the SCIENCE magazine.

Now the teeth can be grown in a test tube

As mentioned in one saying, the teeth is the case. But soon, it seems, it will be possible to nourish artificial teeth, but real. Only teeth grown in vitro. This was stated by Japanese scientists.

Japanese scientists reported that they managed to replace the mouse tooth into the cells grown in the laboratory and functioning likewise initial.

For growing a full-fledged teeth Scientists used primitive cells that cost somewhat higher than stem - mesenchymal and epithelial. The injection of the cellular material was produced in the collagen framework support for the entire body.

After growing tooth They found that it was about 1.3 millimeter with a mature form, which consisted of full parts, such as dentin, pulp, vessels, periodontal fabrics and enamel. Then scientists removed the eight-week mouse cutter and implanted a grown tooth instead. The survey conducted two weeks later showed that the new tooth grows exactly as an ordinary one, it gothes and operates absolutely normal.

Growing tooth It became only the first step in the development of this revolutionary and promising technology.

Thus, the operation was the first successful experience of successful replacement of a whole body with bio-engineering materials. Researchers note that there are two ways. growing tooth: either in organ culture, or in a special capsule attached to the liver of another mouse. The growth process takes 14 days.

This method will allow to grow entire organs from one or two cells, researchers say, although they do not deny that they still have a lot of work to study this truly revolutionary achievement.